Prevalence and Incidence of Respiratory Syncytial Virus and Other Respiratory Viral Infections in Children Aged 6 Months to 10 Years With Influenza-like Illness Enrolled in a Randomized Trial
Terry Nolan, Charissa Borja-Tabora, Pio Lopez, Lily Weckx, Rolando Ulloa-Gutierrez, Eduardo Lazcano-Ponce, Angkool Kerdpanich, Miguel Angel Rodriguez Weber, Abiel Mascarenas de Los Santos, Juan-Carlos Tinoco, Marco Aurelio P Safadi, Lim Fong Seng, Marcela Hernandez-de Mezerville, Idis Faingezicht, Aurelio Cruz-Valdez, Yang Feng, Ping Li, Serge Durviaux, Gerco Haars, Sumita Roy-Ghanta Show all
CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2015
BACKGROUND: The high burden of respiratory syncytial virus (RSV)-associated morbidity and mortality makes vaccine development a priority. METHODS: As part of an efficacy trial of pandemic influenza vaccines (NCT01051661), RSV epidemiology in healthy children aged 6 months to <10 years at first vaccination with influenza-like illness (ILI) was evaluated in Australia, Brazil, Colombia, Costa Rica, Mexico, the Philippines, Singapore, and Thailand between February 2010 and August 2011. Active surveillance for ILI was conducted for approximately 1 year, with nasal and throat swabs analyzed by polymerase chain reaction. The prevalence and incidence of RSV among ILI episodes were calculated. RESULT..View full abstract
This work was supported by GSK Biologicals S.A., which was involved in all stages of study conduct, including analysis of the data, in addition to the costs related to development of this manuscript for publication.