Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia
Tong Zhu, Antonia G Miller, Devy Deliyanti, David R Berka, Alex Agrotis, Duncan J Campbell, Jennifer L Wilkinson-Berka
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | WILEY | Published : 2015
Angiogenesis and inflammation are causative factors in the development of neovascular retinopathies. These processes involve the retinal endothelium and the retinal immune cells, microglia. The renin-angiotensin system contributes to retinal injury via the actions of the type 1 angiotensin receptor (AT1R). However, it has been suggested that prorenin, the initiator of the renin-angiotensin system cascade, influences retinal injury independently from the AT1R. We evaluated whether prorenin induced a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and a pro-inflammatory phenotype in retinal microglia. Primary cultures of retinal endothelial cells and microglia were st..View full abstract
TZ is a recipient of a Monash University PhD Student Scholarship. JW-B is a Senior Research Fellow of the National Health and Medical Research Council of Australia. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program.