Journal article

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

Matthew Read, David Liu, Cuong P Duong, Carleen Cullinane, William K Murray, Christina M Fennell, Jake Shortt, David Westerman, Paul Burton, Nicholas J Clemons, Wayne A Phillips



BACKGROUND: Recently, there has been an increase in the availability of targeted molecular therapies for cancer treatment. The application of these approaches to esophageal cancer, however, has been hampered by the relative lack of appropriate models for preclinical testing. Patient-derived tumor xenograft (PDTX) models are gaining popularity for studying many cancers. Unfortunately, it has proven difficult to generate xenografts from esophageal cancer using these models. The purpose of this study was to improve the engraftment efficiency of esophageal PDTXs. METHODS: Fresh pieces of esophageal tumors obtained from endoscopic biopsies or resected specimens were collected from 23 patients. Th..

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Awarded by NHMRC of Australia Centres for Research Excellence Grant

Funding Acknowledgements

This work was supported by a NHMRC of Australia Centres for Research Excellence Grant (1040947). MR received the Thornell-Shore Memorial scholarship from the Royal Australasian College of Surgeons (RACS) and the Sir Thomas Naghten Fitzgerald scholarship from The University of Melbourne. DL received an NHMRC Australian Postgraduate Research award and Foundation for a Surgery Scholarship from the RACS. JS is supported by the Victorian Cancer Agency/Snowdome Foundation "Eva & Les Erdi Fellowship.'' Some tissue samples used in this Project were provided by the Victorian Cancer Biobank with appropriate ethics approval. The Victorian Cancer Biobank is supported by the Victorian Government, Australia.