Journal article

Clinically Significant Fatigue: Prevalence and Associated Factors in an International Sample of Adults with Multiple Sclerosis Recruited via the Internet

Tracey J Weiland, George A Jelinek, Claudia H Marck, Emily J Hadgkiss, Dania M van der Meer, Naresh G Pereira, Keryn L Taylor



BACKGROUND: Fatigue contributes a significant burden of disease for people with multiple sclerosis (PwMS). Modifiable lifestyle factors have been recognized as having a role in a range of morbidity outcomes in PwMS. There is significant potential to prevent and treat fatigue in PwMS by addressing modifiable risk factors. OBJECTIVES: To explore the associations between clinically significant fatigue and demographic factors, clinical factors (health-related quality of life, disability and relapse rate) and modifiable lifestyle, disease-modifying drugs (DMD) and supplement use in a large international sample of PwMS. METHODS: PwMS were recruited to the study via Web 2.0 platforms and completed ..

View full abstract


Funding Acknowledgements

The authors thank all the participants in the HOLISM study for taking the survey. The authors thank the Bloom Foundation, the Horne Family Charitable Trust, and Elizabeth Schefferle for their grants and donations supporting this study. Professor George Jelinek obtained the funding for this research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.