Journal article

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study

David P Burgner, Matthew A Sabin, Costan G Magnussen, Michael Cheung, Cong Sun, Mika Kahonen, Nina Hutri-Kahonen, Terho Lehtimaki, Eero Jokinen, Tomi Laitinen, Jorma SA Viikari, Olli T Raitakari, Markus Juonala

Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2015

Abstract

OBJECTIVE: Most infections occur in pre-school children but the severity of the inflammatory response to common pathogens varies considerably. We examined the relationship between early childhood infections of sufficient severity to warrant hospitalisation, and markers of subclinical atherosclerosis in adulthood. METHODS: We investigated whether infection-related hospitalisation (IRH) in early childhood (0-5 years) was associated with adverse non-invasive phenotypes of atherosclerosis (carotid artery distensibility and intima-media thickness (IMT), and brachial artery flow-mediated dilation (FMD)) in adulthood in participants from the Cardiovascular Risk in Young Finns study. Analyses were a..

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Grants

Awarded by Academy of Finland


Awarded by Kuopio, Tampere


Awarded by Emil Aaltonen Foundation


Funding Acknowledgements

The Cardiovascular Risk in Young Finns Study is supported by the Academy of Finland (grants 126925, 121584, 124282, 129378 [Salve], 117787 [Gendi], 41071 [Skidi], and 134309 [eye]); the Social Insurance Institution of Finland; the Kuopio, Tampere (grant X51001 for T.L.), and Turku University Hospital Medical Funds; the Paulo Foundation; the Juho Vainio Foundation; the Paavo Nurmi Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Cultural Foundation, the Finnish Medical Foundation, the Sigrid Juselius Foundation; Maud Kuistila Foundation; as well as the Tampere Tuberculosis Foundation and the Emil Aaltonen Foundation. DPB (APP572504, APP1064629) MAS (APP1012201) and CGM (APP1037559) are supported by National Health and Medical Research Council (Australia) Fellowships. DPB is an honorary National Heart Foundation Future Leader Fellow. Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group at Murdoch Childrens Research Institute is supported by RCH100 and the RCH Foundation.