Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
Yi Yuen Wang, Paul Smith, Michael Murphy, Mark Cook
Brain Pathology | WILEY | Published : 2010
Since the inception of global gene expression profiling platforms in the mid-1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with onl..View full abstract
This work is supported by the Royal Australasian College of Surgeons through the John Lowenthal and Foundation Scholarships 2005 and 2006, as well as the St Vincent's Hospital Grant-in-Aids 2005.