Journal article

Perfusion patterns in postictal Tc-99m-HMPAO SPECT after coregistration with MRI in patients with mesial temporal lobe epilepsy

RE Hogan, MJ Cook, DW Binns, PM Desmond, CJ Kilpatrick, VL Murrie, KF Morris

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | BRITISH MED JOURNAL PUBL GROUP | Published : 1997

Abstract

OBJECTIVES: To assess patterns of postictal cerebral blood flow in the mesial temporal lobe by coregistration of postictal 99mTc-HMPAO SPECT with MRI in patients with confirmed mesial temporal lobe epilepsy. METHODS: Ten postictal and interictal 99mTc-HMPAO SPECT scans were coregistered with MRI in 10 patients with confirmed mesial temporal lobe epilepsy. Volumetric tracings of the hippocampus and amygdala from the MRI were superimposed on the postictal and interictal SPECT. Asymmetries in hippocampal and amygdala SPECT signal were then calculated using the equation: % Asymmetry =100 x (right - left) / (right + left)/2. RESULTS: In the postictal studies, quantitative measurements of amygdala..

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