Journal article
Antimicrobial protein and peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis
S Trend, T Strunk, J Hibbert, CH Kok, G Zhang, DA Doherty, P Richmond, D Burgner, K Simmer, DJ Davidson, AJ Currie
Plos One | Published : 2015
Abstract
Objective: We investigated the levels and antimicrobial activity of antimicrobial proteins and peptides (AMPs) in breast milk consumed by preterm infants, and whether deficiencies of these factors were associated with late-onset neonatal sepsis (LOS), a bacterial infection that frequently occurs in preterm infants in the neonatal period. Study design: Breast milk from mothers of preterm infants (≤32 weeks gestation) was collected on days 7 (n = 88) and 21 (n = 77) postpartum. Concentrations of lactoferrin, LL-37, beta-defensins 1 and 2, and alpha-defensin 5 were measured by enzyme-linked immunosorbent assay. The antimicrobial activity of breast milk samples against Staphylococcus epidermidis..
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Awarded by Medical Research Council
Funding Acknowledgements
Funding for this study was awarded to AC, TS, KS, PR, DAD and DB by the National Health and Medical Research Council (572548; www.nhmrc.gov.au), to AC, TS, KS and DB from the Princess Margaret Hospital Foundation (www.pmhfoundation.com), to AC, DJD, TS, and DB from the Telethon New Childrens Hospital Research Fund (http://www.health.wa.gov.au), and to TS from the Clive and Vera Ramaciotti Foundation (www.perpetual.com.au/ramaciotti). DJD is supported by a Medical Research Council Senior Non-clinical Fellowship (G1002046; http://www.mrc.ac.uk) and a Distinguished Collaborator Award from Murdoch University (www.murdoch.edu.au). DB is supported by a National Health and Medical Research Council Senior Research Fellowship (APP1064629; www.nhmrc.gov.au) and an Honorary National Heart Foundation Australia Future Leader Fellowship (100026; www.heartfoundation.org.au). Research at the Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program (www.vic.gov.au). GZ is supported by a Brightspark Foundation Fellowship (www.brightsparkfoundation.com.au). ST is supported by an Australian postgraduate award (www.education.gov.au), and postgraduate scholarships from the Women and Infants Research Foundation (www.wirf.com.au) and the Princess Margaret Hospital Foundation (www.pmhfoundation.com). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.