Journal article
Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle
PL Van Der Peet, C Gunawan, S Torigoe, S Yamasaki, SJ Williams
Chemical Communications | Published : 2015
DOI: 10.1039/c5cc00085h
Abstract
An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.
Grants
Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This work was supported by the Australian Research Council and the JSPS Grant-in-Aid for Scientific Research. We thank Profs Mark Rizzacasa and Ian Paterson for helpful advice.