Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans
Tasha K Mendes, Stevan Novakovic, Greta Raymant, Sonja E Bertram, Reza Esmaillie, Saravanapriah Nadarajan, Bert Breugelmans, Andreas Hofmann, Robin B Gasser, Monica P Colaiacovo, Peter R Boag
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015
RIO protein kinases (RIOKs) are a relatively conserved family of enzymes implicated in cell cycle control and ribosomal RNA processing. Despite their functional importance, they remain a poorly understood group of kinases in multicellular organisms. Here, we show that the C. elegans genome contains one member of each of the three RIOK sub-families and that each of the genes coding for them has a unique tissue expression pattern. Our analysis showed that the gene encoding RIOK-1 (riok-1) was broadly and strongly expressed. Interestingly, the intestinal expression of riok-1 was dependent upon two putative binding sites for the oxidative and xenobiotic stress response transcription factor SKN-1..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
This work was supported by a National Health and Medical Research Council grant, APP1044022 (RBG, PRB & AH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.