Journal article

Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans

Tasha K Mendes, Stevan Novakovic, Greta Raymant, Sonja E Bertram, Reza Esmaillie, Saravanapriah Nadarajan, Bert Breugelmans, Andreas Hofmann, Robin B Gasser, Monica P Colaiacovo, Peter R Boag

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015


RIO protein kinases (RIOKs) are a relatively conserved family of enzymes implicated in cell cycle control and ribosomal RNA processing. Despite their functional importance, they remain a poorly understood group of kinases in multicellular organisms. Here, we show that the C. elegans genome contains one member of each of the three RIOK sub-families and that each of the genes coding for them has a unique tissue expression pattern. Our analysis showed that the gene encoding RIOK-1 (riok-1) was broadly and strongly expressed. Interestingly, the intestinal expression of riok-1 was dependent upon two putative binding sites for the oxidative and xenobiotic stress response transcription factor SKN-1..

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University of Melbourne Researchers