ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven Goossens; Enrico Radaelli; Odile Blanchet; Kaat Durinck; Joni Van der Meulen; Sofie Peirs; Tom Taghon; Cedric S Tremblay; Magdaline Costa; Morvarid Farhang Ghahremani; Jelle De Medts; Sonia Bartunkova; Katharina Haigh; Claire Schwab; Natalie Farla; Tim Pieters; Filip Matthijssens; Nadine Van Roy; J Adam Best; Kim Deswarte; Pieter Bogaert; Catherine Carmichael; Adam Rickard; Santi Suryani; Lauryn S Bracken; Raed Alserihi; Kirsten Cante-Barret; Lieven Haenebalcke; Emmanuelle Clappier; Pieter Rondou; Karolina Slowicka; Danny Huylebroeck; Ananda W Goldrath; Viktor Janzen; Matthew P McCormack; Richard B Lock; David J Curtis; Christine Harrison; Geert Berx; Frank Speleman; Jules PP Meijerink; Jean Soulier; Pieter Van Vlierberghe; Jody J Haigh

Journal article

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven Goossens, Enrico Radaelli, Odile Blanchet, Kaat Durinck, Joni Van der Meulen, Sofie Peirs, Tom Taghon, Cedric S Tremblay, Magdaline Costa, Morvarid Farhang Ghahremani, Jelle De Medts, Sonia Bartunkova, Katharina Haigh, Claire Schwab, Natalie Farla, Tim Pieters, Filip Matthijssens, Nadine Van Roy, J Adam Best, Kim Deswarte Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2015

DOI: 10.1038/ncomms6794

University of Melbourne Researchers

David Curtis Author Medicine - Royal Melbourne Hospital

Grants

Awarded by Fund for Scientific Research-Flanders (FWO-V)

Awarded by European Hematology Association (EHA)

Awarded by Australian NHMRC grant

Awarded by Children Cancer Free Foundation (Stichting Kinderen Kankervrij)

Awarded by ERC St-Grant Consolidator

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

This work was supported by the Fund for Scientific Research-Flanders (FWO-V; G056813N to JJH and 3G002711 to T. T.) as well as the Belgian Federation for the Study Against Cancer (BFAC) and the European Hematology Association (EHA; 2009/26) and the Australian NHMRC grant 1047995. The work is part of the DevRepair (P7/07) IAP-VII network. P. V. V. and T. T. are the recipients of an Odysseus type II grant. S. G., T. T., P. V. V. and P. R. are postdoctoral fellows and J.V. derM. is a PhD student supported by the FWO-V. K.C.-B. is financially supported by The Children Cancer Free Foundation (Stichting Kinderen Kankervrij; KIKA2008-029). L. H. and K. D. are funded by PhD grants of the Agency for Innovation by Science and Technology (IWT). D. H. was supported by a visiting professorship awarded by the Royal Dutch Academy of Arts and Sciences to work at Erasmus MC, Rotterdam. J.S. is supported by a Ligue Contre le Cancer grant programme Carte d'Identite des tumeurs (CIT), the SLI programme from the French Agence National pour la Recherche, and by an ERC St-Grant Consolidator 311660-CEVAL. We thank Daisy Ginneberge and Gert Van Isterdaele for their help with the FACS cell sorting, and Niels Vandamme for help with the transplants.