Journal article

DISTENSION-EVOKED ASCENDING AND DESCENDING REFLEXES IN THE CIRCULAR MUSCLE OF GUINEA-PIG ILEUM - AN INTRACELLULAR STUDY

TK SMITH, JC BORNSTEIN, JB FURNESS

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | ELSEVIER SCIENCE BV | Published : 1990

Abstract

Reflex responses evoked by distension of the guinea-pig small intestine were recorded from the circular muscle with intracellular microelectrodes. For this purpose a mechanically stable preparation that allowed the intestinal wall to be distended within 9 mm of the recording site was developed. A segment of intestine was opened along the mesenteric border and pinned mucosa uppermost over a balloon set in the base of an organ bath, so that inflation of the balloon could distend the intestinal wall without simultaneously pushing against the mucosa. Compound excitatory junction potentials (EJPs) and compound inhibitory junction potentials (IJPs) were recorded at sites up to 40 mm oral and anal ..

View full abstract