Journal article

NEUROPEPTIDES CONTAINED IN PERIPHERAL CARDIOVASCULAR NERVES

JB FURNESS, M COSTA, RE PAPKA, NG DELLA, R MURPHY

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | MARCEL DEKKER INC | Published : 1984

Abstract

The neuropeptides, substance P, vasoactive intestinal peptide (VIP), neuropeptide Y and enkephalin have been found in nerves associated with the heart and blood vessels of a range of mammals, including man. There is also evidence for some cardiovascular nerves with gastrin releasing peptide and neurotensin immunoreactivity. Substance P is in sensory nerves with a widespread distribution to the heart and all vascular beds. In general, large arteries have the densest innervation and the density of nerves decreases as arterial size decreases. In adult guinea-pigs, an adequate treatment with capsaicin causes the degeneration of almost all cardiovascular substance P nerves. Using capsaicin as a t..

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University of Melbourne Researchers