SIMULTANEOUS INTRACELLULAR-RECORDINGS FROM ENTERIC NEURONS REVEAL THAT MYENTERIC AH NEURONS TRANSMIT VIA SLOW EXCITATORY POSTSYNAPTIC POTENTIALS

Abstract

Simultaneous intracellular electrical recordings were made from pairs of neurons separated circumferentially by 100-200 microns of the myenteric plexus of the guinea-pig ileum in vitro. The recording electrodes were filled with the dye neurobiotin which was injected into impaled nerve cells, and later revealed histochemically. Intracellular current pulses were used to evoke action potentials via the recording electrode in one type of myenteric neuron, in most cases an AH neuron, while a second electrode was used to record from a simultaneously impaled S neuron or AH neuron. AH neurons are thought to be primary sensory neurons, whereas S neurons are interneurons and motor neurons. Ninety pair..