Journal article

THE RELATIONSHIP BETWEEN GASTRIN CELLS AND BOMBESIN-LIKE IMMUNOREACTIVE NERVE-FIBERS IN THE GASTRIC ANTRAL MUCOSA OF GUINEA-PIG, RAT, DOG AND MAN

AS MILLER, JB FURNESS, M COSTA

CELL AND TISSUE RESEARCH | SPRINGER VERLAG | Published : 1989

Abstract

The relationship between bombesin-like immunoreactive (bombesin-LI) nerve fibres and gastrin-LI G-cells was examined in gastric antral mucosa from guinea-pig, rat, dog and man using a double-labelling fluorescence immunohistochemical technique. The greatest density of bombesin-LI nerve fibres was found within the basal mucosa in all species and the density of innervation decreased towards the luminal surface. Most G-cells were in a band occupying approximately the middle third of the mucosa. The proportion of G-cells found within a distance of 2 microns from bombesin-LI nerve fibres was low in all species (6% in the guinea-pig, 22% in the rat, 14% in the dog, and 9% in the human). It is prop..

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University of Melbourne Researchers