Journal article

DISTRIBUTION OF INTRINSIC NERVE-CELL BODIES AND AXONS WHICH TAKE UP AROMATIC-AMINES AND THEIR PRECURSORS IN SMALL-INTESTINE OF GUINEA-PIG

JB FURNESS, M COSTA

CELL AND TISSUE RESEARCH | SPRINGER | Published : 1978

Abstract

The sites of uptake, decarboxylation and retention of 1-dopa and the uptake and retention of dopamine and 6-hydroxytryptamine in the small intestine of the guinea-pig have been localised histochemically with a fluorescence technique for arylethylamines. In segments of ileum from untreated guinea-pigs only noradrenergic axons are fluorescent; these axons were eliminated by surgical denervation (crushing nerves running to the intestine through the mesentery) or by chemical denervation with 6-hydroxydopamine. In denervated segments of ileum, cell bodies and processes of intrinsic neurons become fluorescent after the injection of 1-dopa, dopamine or 6-hydroxytryptamine and the inhibition of mono..

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University of Melbourne Researchers