Journal article

REFLEX CHANGES IN CIRCULAR MUSCLE-ACTIVITY ELICITED BY STROKING THE MUCOSA - AN ELECTROPHYSIOLOGICAL ANALYSIS IN THE ISOLATED GUINEA-PIG ILEUM

TK SMITH, JB FURNESS

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | ELSEVIER SCIENCE BV | Published : 1988

Abstract

A preparation of isolated small intestine from the guinea-pig was studied in which reflex responses of the circular muscle were recorded intracellularly when sensory receptors in the mucosa were stimulated mechanically. This preparation was used to examine the properties of mucosa to muscle reflexes that involve non-cholinergic motor neurons innervating the circular muscle. Reproducible stimulation of the mucosa was achieved by stroking with a motor-driven brush. Gentle brush-strokes applied to the mucosa typically evoked inhibitory junction potentials anal to the stimulus and excitatory junction potentials at recording sites oral to the stimulus. Both events were rapid in onset and up to 25..

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