Journal article

INTRINSIC AND EXTRINSIC INHIBITORY SYNAPTIC INPUTS TO SUBMUCOUS NEURONS OF THE GUINEA-PIG SMALL-INTESTINE

JC BORNSTEIN, M COSTA, JB FURNESS

JOURNAL OF PHYSIOLOGY-LONDON | CAMBRIDGE UNIV PRESS | Published : 1988

Abstract

1. The sources of inhibitory synaptic inputs to neurones in submucous ganglia of the guinea-pig small intestine were examined by making lesions to cause selective degeneration of nerve terminals of sympathetic or intrinsic origin. Intracellular recordings were used to evaluate the effects of lesions on the inhibitory inputs. Immunohistochemical techniques were used to identify the neurochemical classes of the impaled neurones and to confirm the efficacy of the lesions. 2. The neurones from which recordings were taken were filled with the fluorescent dye Lucifer Yellow. The preparations were then fixed and processed for immunohistochemistry. 3. Thirty-one neurones reactive for vasoactive inte..

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