Journal article

ABNORMALITIES OF PEPTIDE-CONTAINING NERVE-FIBERS IN INFANTILE HYPERTROPHIC PYLORIC-STENOSIS

DA WATTCHOW, DT CASS, JB FURNESS, M COSTA, PE OBRIEN, KE LITTLE, J PITKIN

GASTROENTEROLOGY | W B SAUNDERS CO | Published : 1987

Abstract

The distributions of nerve cells and fibers with immunoreactivity for the peptides enkephalin, gastrin-releasing peptide, neuropeptide Y, somatostatin, substance P, and vasoactive intestinal peptide were examined in specimens of myenteric plexus and external muscle from the pylorus of 20 infants with hypertrophic pyloric stenosis. These were compared with peptide distributions in pyloric samples from unaffected infants and adults. In the normal pylorus the circular muscle was richly supplied with fibers reactive for enkephalin, neuropeptide Y, substance P, and vasoactive intestinal peptide. In pyloric stenosis, these immunoreactive fiber bundles were either missing or less than 5% of normal...

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