Journal article

PARTIAL DEPLETION OF NEUROPEPTIDE-Y FROM NORADRENERGIC PERIVASCULAR AND CARDIAC AXONS BY 6-HYDROXYDOPAMINE AND RESERPINE

JL MORRIS, R MURPHY, JB FURNESS, M COSTA

REGULATORY PEPTIDES | ELSEVIER SCIENCE BV | Published : 1986

Abstract

The effects of 6-hydroxydopamine (6-OHDA) and reserpine on the storage of neuropeptide Y (NPY) in noradrenergic cardiovascular nerves were examined with both immunohistochemistry and radioimmunoassay (RIA). Immunohistochemical double-labelling techniques demonstrated that NPY was located only in noradrenergic axons in the guinea-pig carotid artery, mitral valve, thoracic inferior vena cava, thoracic aorta, superior mesenteric artery and small saphenous vein. Treatment with 6-OHDA in vivo eliminated noradrenergic, NPY-containing axon terminals from all tissues, but preterminal axons were still prominent in the superior mesenteric artery. The greatest depletion of NPY detected by RIA after 6-O..

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