Journal article

CO-LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY WITH SUBSTANCE-P IN CUTANEOUS, VASCULAR AND VISCERAL SENSORY NEURONS OF GUINEA-PIGS

IL GIBBINS, JB FURNESS, M COSTA, I MACINTYRE, CJ HILLYARD, S GIRGIS

NEUROSCIENCE LETTERS | ELSEVIER SCI IRELAND LTD | Published : 1985

Abstract

Calcitonin gene-related peptide (CGRP) has been immunohistochemically co-localized with substance P (SP) in capsaicin-sensitive, varicose axons supplying the skin, viscera and cardiovascular system of the guinea pig. After treatment with colchicine in vitro, 82% of SP neurons in the dorsal root ganglia contained CGRP-like immunoreactivity while 96% of CGRP neurons were immunoreactive for SP. Both CGRP- and SP-like immunoreactive material are transported peripherally and centrally from dorsal root ganglia. Thus, in tissues such as the gut where there are intrinsic nerves containing SP but lacking CGRP, CGRP-like immunoreactivity is a useful means of specifically labelling axons of most sensor..

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University of Melbourne Researchers