Journal article

SUBSTANCE P-CONTAINING NERVES IN THE HUMAN SMALL-INTESTINE - DISTRIBUTION, ULTRASTRUCTURE, AND CHARACTERIZATION OF THE IMMUNOREACTIVE PEPTIDE

IJ LLEWELLYNSMITH, JB FURNESS, R MURPHY, PE OBRIEN, M COSTA

GASTROENTEROLOGY | W B SAUNDERS CO | Published : 1984

Abstract

Light and electron microscopic immunocytochemical techniques were used to examine the distribution and ultrastructure of substance P-immunoreactive nerves in human jejunum and distal ileum. The organization of human enteric substance P-containing nerves closely resembled that in other species. Dense arrays of varicose immunofluorescent fibers occurred in myenteric and submucous ganglia (which contained immunoreactive nerve cell bodies) and in the mucosa. There were fibers in both muscle layers, in the muscularis mucosae, and around blood vessels. Fibers in the myenteric plexus contributed to both ascending and descending pathways. Substance P-immunoreactive axon profiles contained small roun..

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