Journal article

AN IMMUNOHISTOCHEMICAL STUDY OF THE PROJECTIONS OF SOMATOSTATIN-CONTAINING NEURONS IN THE GUINEA-PIG INTESTINE

M COSTA, JB FURNESS, IJL SMITH, B DAVIES, J OLIVER

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1980

Abstract

Somatostatin-like immunoreactivity was localized in nerves in whole mount preparations of the separated layers of the guinea-pig intestine. The directions in which the neurons project were determined by examining the accumulation of somatostatin-like immunoreactivity after axonal flow was interrupted. In some experiments this was done by crushing or cutting the nerves in isolated preparations which were then maintained in oxygenated Krebs solution for 3-5 h. In other experiments, the nerves were cut in vivo and the animals allowed to survive for 4-8 days before the intestine was examined. Somatostatin immunoreactive nerve cell bodies were found in both the myenteric plexus, where they repres..

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