Journal article

DISTRIBUTION OF ADRENERGIC NERVES AND CHANGES IN NEUROMUSCULAR TRANSMISSION IN MOUSE VAS DEFERENS DURING POSTNATAL DEVELOPMENT

JB FURNESS, JR MCLEAN, G BURNSTOCK

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 1970

Abstract

Fluorescence due to catecholamines is first observed in longitudinally orientated nerve bundles during the first postnatal day. Fine fluorescent nerves are present within the circular muscle coat by the postnatal day 5 and in the longitudinal coat from about day 9. The density of this innervation increases rapidly with the development of the muscle coats. The resting membrane polarization of the smooth muscle cells increased with age, from 67 mV at 10 days to 74 mV at 6 months. Excitatory junction potentials (EJP's) in response to intrinsic nerve stimulation were not observed for mice of less than 18 days. The EJP's evoked in vasa from mice of from 18 days to 25-30 days decayed from peak amp..

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University of Melbourne Researchers