Journal article

Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103

JA Pearce, K Mills, T Triglia, AF Cowman, RF Anders

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | ELSEVIER SCIENCE BV | Published : 2005

Abstract

The merozoite surface of the pathogenic malaria parasite Plasmodium falciparum is comprised of proteins that are important for the identification and invasion of human red cells. Merozoite surface protein (MSP)3 is a polymorphic protein associated with the surface of merozoites and is also a vaccine candidate. A distinct feature of the MSP3 sequence is three blocks of alanine-rich heptad repeats that are predicted to form an intramolecular coiled-coil. Three orthologues of MSP3 that also contain alanine-rich heptad repeats have been described in P. vivax and we therefore searched the P. falciparum genome database for MSP3 paralogues. We have identified two genes, H101 and H103 related to MSP..

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