Journal article

Impact of Reticular Pseudodrusen on Microperimetry and Multifocal Electroretinography in Intermediate Age-Related Macular Degeneration

Zhichao Wu, Lauren N Ayton, Galina Makeyeva, Robyn H Guymer, Chi D Luu

Investigative Ophthalmology & Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2015

Abstract

PURPOSE: To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. METHODS: In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared reflectance imaging and spectral-domain optical coherence tomography (SD-OCT) scans were performed in 120 eyes from 60 participants with bilateral intermediate AMD. The number of subfields with pigmentary changes and RPD within the central 3-mm diameter of the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid and drusen cube root volume within the central 3-mm diameter wa..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) (Canberra, ACT, Australia)


Awarded by University of Melbourne Early Career Research Grant (Parkville, VIC, Australia)


Awarded by NHMRC Centre for Clinical Research Excellence Award


Funding Acknowledgements

Supported by the National Health and Medical Research Council (NHMRC) Project Grant (#1027624; Canberra, ACT, Australia), Macular Disease Foundation Australia (MDFA) Research Grant (Sydney, NSW, Australia), Bupa Health Foundation (Sydney, NSW, Australia), BrightFocus Foundation (Clarksburg, MD, USA), a University of Melbourne Early Career Research Grant (LNA, #1350114; Parkville, VIC, Australia) and the Menzies Foundation (East Melbourne, VIC, Australia). CERA receives Operational Infrastructure Support from the Victorian Government and is supported by a NHMRC Centre for Clinical Research Excellence Award (#529923).