68Ga-EDTA PET/CT imaging and plasma clearance for glomerular filtration rate quantification: Comparison to conventional 51Cr-EDTA

Abstract

Glomerular filtration rate (GFR) can accurately be determined using 51Cr-ethylenediaminetetraacetic acid (EDTA) plasma clearance counting but is time-consuming and requires technical skills and equipment not always available in imaging departments. 68Ga-EDTA can be readily available using an onsite generator, and PET/CT enables both imaging of renal function and accurate camera-based quantitation of clearance of activity from blood and its appearance in the urine. This study aimed to assess agreement between 68Ga-EDTA GFR (68Ga-GFR) and 51Cr-EDTA GFR (51Cr-GFR), using serial plasma sampling and PET imaging. Methods: 68Ga-EDTA and 51Cr-EDTA were injected concurrently in 31 patients. Dynamic P..