Journal article
Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines
N Caccamo, G Pietra, LC Sullivan, AG Brooks, T Prezzemolo, MP La Manna, D Di liberto, SA Joosten, KE van Meijgaarden, P Di Carlo, L Titone, L Moretta, MC Mingari, THM Ottenhoff, F Dieli
European Journal of Immunology | Published : 2015
Abstract
CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides associated to classical MHC class Ia molecules, but little information is available on CD8 T cells recognizing M. tuberculosis Ags presented by nonclassical MHC class Ib molecules. We show here that CD8 T cells from tuberculosis (TB) patients recognize HLA-E-binding M. tuberculosis peptides in a CD3/TCR αβ mediated and CD8-dependent manner, and represent an additional type of effector cells playing a role in immune response to M. tuberculosis during active infection. HLA-E-restricted recognition of M. tuberculosis peptides is detectabl..
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Awarded by European Commission
Funding Acknowledgements
The authors acknowledge J. E. Coligan, E. H. Weiss, V. Horejsi, G. Triolo, H. Walczak, and A. Krensky for providing reagents. This work was supported by grants from the European Commission within the 6th Framework Programme, TBVAC contract no. LSHP-CT-2003-503367, and the 7th Framework Programme, NEWTBVAC contract no. HEALTH-F3-2009-241745, to T. H. M. O. and F. D. The text represents the authors' views and does not necessarily represent a position of the Commission, which will not be liable for the use made of such information.