Book Chapter

Cell-Cell Interactions Driving Kidney Morphogenesis

Alexander N Combes, Jamie A Davies, Melissa H Little

CELLULAR ADHESION IN DEVELOPMENT AND DISEASE | Current Topics in Developmental Biology | ELSEVIER ACADEMIC PRESS INC | Published : 2015

Abstract

The mammalian kidney forms via cell-cell interactions between an epithelial outgrowth of the nephric duct and the surrounding nephrogenic mesenchyme. Initial morphogenetic events include ureteric bud branching to form the collecting duct (CD) tree and mesenchymal-to-epithelial transitions to form the nephrons, requiring reciprocal induction between adjacent mesenchyme and epithelial cells. Within the tips of the branching ureteric epithelium, cells respond to mesenchyme-derived trophic factors by proliferation, migration, and mitosis-associated cell dispersal. Self-inhibition signals from one tip to another play a role in branch patterning. The position, survival, and fate of the nephrogenic..

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