An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo
Brandon J Aubrey, Gemma L Kelly, Andrew J Kueh, Margs S Brennan, Liam O'Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J Herold
Cell Reports | CELL PRESS | Published : 2015
Awarded by Kay Kendall Leukemia Fund Intermediate Fellowship
Awarded by National Health and Medical Research Council, Australia program
Awarded by Leukemia and Lymphoma Society SCOR
We thank all members of the M.J.H. laboratory for their support and advice; D. Gray for critical reading of the manuscript; G. Siciliano, C. Gatt, and their team for animal husbandry; S. Monard and his team for help with the flow cytometry unit; A.B. Rickinson and M. Rowe (University of Birmingham) for the kind gift of BL cell lines; and K. Rogers and the WEHI imaging facility. This work was supported by a Leukemia Foundation National Research Program Clinical PhD Scholarship (to B.J.A.), a Kay Kendall Leukemia Fund Intermediate Fellowship (KKL331 to G.L.K.); the National Health and Medical Research Council, Australia program grant 1016701 and fellowship 1020363, Leukemia and Lymphoma Society SCOR grant 7001-13 (to A.S.), and project grant GNT1049720 (to M.J.H.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme.