Journal article
Exploring features and function of Ss-riok-3, an enigmatic kinase gene from Strongyloides stercoralis
W Yuan, Y Liu, JB Lok, JD Stoltzfus, RB Gasser, W Lei, R Fang, undefined Junlong Zhao, M Hu
Parasites and Vectors | BMC | Published : 2014
Abstract
Background: Right open reading frame protein kinase 3 (RIOK-3) belongs to the atypical kinase family. Unlike th other two members, RIOK-1 and RIOK-2, which are conserved from Archaea to humans, RIOK-3 occurs only i multicellular organisms. Studies on HeLa cells indicate that human RIOK-3 is a component of the 40S small ribosom subunit and supports cancer cell growth and survival. However, almost nothing is known about the function of RIOK-3 We explored the functional role of RIOK-3 encoding gene from Strongyloides stercoralis, a parasitic nematode of human and dogs Methods: To analyze the gene and promoter structure of Ss-riok-3, RACE-PCR and Genome-walker PCR were performe to isolate the fu..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
Sincere thanks to Hongguang Shao and Xinshe Li for assistance with gonad injection in S. stercoralis. This study was supported by the Special Fund for Agro-scientific Research in the Public Interest (Grant No. 201303037) and the Fundamental Research Funds for the Central Universities (Program no. 2011PY118) to MH, and by grants from the National Institutes of Health (NIH), USA (AI-050688, AI-082548 and AI-105856) to JBL. Funds from the National Health and Medical Research Council (NHMRC) of Australia and the Australian Research Council (ARC) are gratefully acknowledged (RBG); this study was also supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0007 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (RBG). Other support from the Australian Academy of Science and the Alexander von Humboldt Foundation is gratefully acknowledged (RBG).