Journal article

Self-assembling dual component nanoparticles with endosomal escape capability

Adelene SM Wong, Sarah K Mann, Ewa Czuba, Audrey Sahut, Haiyin Liu, Tiffany C Suekama, Tayla Bickerton, Angus PR Johnston, Georgina K Such

Soft Matter | ROYAL SOC CHEMISTRY | Published : 2015

Abstract

This study reports a novel nanoparticle system with simple and modular one-step assembly, which can respond intelligently to biologically relevant variations in pH. Importantly, these particles also show the ability to induce escape from the endosomal/lysosomal compartments of the cell, which is integral to the design of efficient polymeric delivery systems. The nanoparticles were formed by the nanoprecipitation of pH-responsive poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) and poly(2-(diethylamino)ethyl methacrylate)-b-poly(ethylene glycol) (PDEAEMA-b-PEG). Rhodamine B octadecyl ester perchlorate was successfully encapsulated within the hydrophobic core of the nanoparticle upon nanopre..

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