Pnenotype switching in melanoma: implications for progression and therapy
Frederic Zhentao Li, Amardeep Singh Dhillon, Robin L Anderson, Grant McArthur, Petranel T Ferrao
FRONTIERS IN ONCOLOGY | FRONTIERS MEDIA SA | Published : 2015
Epithelial-mesenchymal transition (EMT) is a key process associated with the progression of epithelial cancers to metastatic disease. In melanoma, a similar process of phenotype switching has been reported and EMT-related genes have been implicated in promotion to a metastatic state. This review examines recent research on the role of signaling pathways and transcription factors regulating EMT-like processes in melanoma and their association with response to therapy in patients, especially response to BRAF inhibition, which is initially effective but limited by development of resistance and subsequent progression. We highlight studies implicating specific roles of various receptor tyrosine k..View full abstract
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Awarded by NHMRC
Awarded by National Breast Cancer Foundation
FL is supported by the China's Scholarship Council of the Education Ministry of the China. This work is supported by an NHMRC Project grant to PF (1042980) and an NHMRC program grant to GM. GM is the Lorenzo Galli Chair in melanoma and Skin Cancers, University of Melbourne.