Journal article

Pnenotype switching in melanoma: implications for progression and therapy

Frederic Zhentao Li, Amardeep Singh Dhillon, Robin L Anderson, Grant McArthur, Petranel T Ferrao

FRONTIERS IN ONCOLOGY | FRONTIERS MEDIA SA | Published : 2015

Abstract

Epithelial-mesenchymal transition (EMT) is a key process associated with the progression of epithelial cancers to metastatic disease. In melanoma, a similar process of phenotype switching has been reported and EMT-related genes have been implicated in promotion to a metastatic state. This review examines recent research on the role of signaling pathways and transcription factors regulating EMT-like processes in melanoma and their association with response to therapy in patients, especially response to BRAF inhibition, which is initially effective but limited by development of resistance and subsequent progression. We highlight studies implicating specific roles of various receptor tyrosine k..

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