Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth

Abstract

Purpose. There is now considerable evidence that FGF is involved in lens differentiation and growth throughout life. The aim of this study was to determine potential sites of FGF production in and near the lens during morphogenesis, differentiation and growth. Methods. The distribution of FGF-1 and FGF-2 mRNAs was analysed in embryonic, weanling and adult rat eyes by in situ hybridization. Results. During lens morphogenesis, there was distinct expression of FGF-1, but not FCF-2, in the lens placode and retinal disc cells. Subsequently, both forms of FGF showed similar expression patterns. During lens differentiation, distinct expression of FGFs was associated with elongating primary fiber ce..