Journal article

A PHARMACOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF THE SPLANCHNIC INNERVATION OF ILEAL LONGITUDINAL MUSCLE IN THE TOAD BUFO-MARINUS

P OSBORNE, G CAMPBELL

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | SPRINGER | Published : 1986

Abstract

A study was made of the innervation of the longitudinal muscle of the toad ileum with particular emphasis on the splanchnic innervation by non-adrenergic, non-cholinergic (NANC) nerves. Nerve fibres containing substance P-like immunoreactivity (SP-LI) were observed in the gut wall and in the ileal wall after degenerative section of the splanchnic nerves. Incubation overnight in a high concentration of capsaicin (3 X 10(-4) M) caused degeneration of SP-LI fibres. No evidence was obtained for enteric neurons containing SP-LI. Substance P caused a contraction of the longitudinal muscle similar to that produced by nerve stimulation. The response to nerve stimulation was decreased by about 60% by..

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