Journal article

Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin

Agnes W Wong, James KP Yeung, Sophie C Payne, Janet R Keast, Peregrine B Osborne

MOLECULAR AND CELLULAR NEUROSCIENCE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

Abstract

Neurotrophic factors have been intensively studied as potential therapeutic agents for promoting neural regeneration and functional recovery after nerve injury. Artemin is a member of the glial cell line-derived neurotrophic factor (GDNF) family of ligands (GFLs) that forms a signalling complex with GFRα3 and the tyrosine kinase Ret. Systemic administration of artemin in rodents is reported to facilitate regeneration of primary sensory neurons following axotomy, improve recovery of sensory function, and reduce sensory hypersensitivity that is a cause of pain. However, the biological mechanisms that underlie these effects are mostly unknown. This study has investigated the biological signific..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia: Senior Research Fellowship #632903 to JRK, and Project Grant #1022914 to JRK and #1024552 to PBO. AWW, JKPY and SCP participated in conducting the experimental work. JRK and PBO contributed to conception and design of the study. AWW, JKPY, JRK and PBO contributed to analysis or interpretation of the data and writing the manuscript. The authors have no conflicts of interest to declare.