Journal article

Activation of alpha- and beta-adrenoceptors by sympathetic nerve stimulation in the large intestine of the rat

GB Luckensmeyer, JR Keast

JOURNAL OF PHYSIOLOGY-LONDON | CAMBRIDGE UNIV PRESS | Published : 1998

Abstract

1. The effects of sympathetic nerve stimulation on the motility of the circular and longitudinal muscle of the large intestine were investigated in vitro, and the involvement of various adrenoceptor subtypes determined. A comparison between the sympathetic supply arising from the prevertebral and pelvic ganglia was also made. 2. In the longitudinal muscle of the distal colon, sympathetic nerve stimulation caused responses which were contractile (0.1-2 Hz), biphasic (5-10 Hz) or purely inhibitory (20-30 Hz). All contractile responses were removed with phentolamine (3 microM), whereas the inhibitory responses were significantly diminished by propranolol (0.1 microM) and completely abolished by..

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University of Melbourne Researchers