SP-IMMUNOREACTIVE AND CGRP-IMMUNOREACTIVE AXONS DIFFER IN THEIR ABILITY TO REINNERVATE THE SKIN OF THE RAT TAIL
EM MCLACHLAN, JR KEAST, M BAUER
NEUROSCIENCE LETTERS | ELSEVIER SCI IRELAND LTD | Published : 1994
The reinnervation of cutaneous targets was studied in the rat tail after proximal lesions of all collector nerves. The distribution of immunofluorescent nerve fibres stained for calcitonin-gene-related peptide (CGRP) and substance P (SP) was examined after 110-210 days. Targets at all sites were reinnervated by CGRP-immunoreactive (IR) fibres. However, SP-IR terminals were rare, particularly distally, despite staining within subdermal nerve trunks.