Journal article
Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes
P Requena, D Barrios, LJ Robinson, P Samol, AJ Umbers, R Wangnapi, M Ome-Kaius, A Rosanas-Urgell, A Mayor, M López, E De Lazzari, M Arévalo-Herrera, C Fernández-Becerra, H Del Portillo, CE Chitnis, PM Siba, S Rogerson, I Mueller, A Bardají, C Menéndez Show all
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2015
Abstract
Pregnancy triggers immunological changes aimed to tolerate the fetus. However, it has not been properly addressed whether similar changes occur in tropical areas with high infection pressure and whether these changes render women more susceptible to infectious diseases. We compared the frequencies of T cell subsets, including regulatory T cells, in pregnant and nonpregnant women from Papua New Guinea, a high malaria transmission area, and from Spain, a malaria-free country. We also assessed the relationship among these cellular subsets, malaria infection, and delivery outcomes. CD4+FOXP3+CD127low T cells (Tregs) were decreased in pregnant women in both countries but were not associated with ..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
The PREGVAX project was supported by European Union Seventh Framework Programme (FP7/2007-2013) Grant 201588 and cofunding from the Ministerio de Economia y Competitividad (National R&D Internationalization Program, EUROSALUD 2008, Spain) Grant EUS2009-03560. In addition, Papua New Guinea studies received cofunding from the Malaria in Pregnancy Consortium through the Bill & Melinda Gates Foundation (Grant 46099). C.D. was supported by a fellowship from the Ministerio de Economia y Competitividad (Grant RYC-2008-02631). I.M. was supported by a National Health and Medical Research Council Senior Research Fellowship (Grant GNT1043345). L.J.R. was supported by a National Health and Medical Research Council Early Career Fellowship (Grant 1016443). A.M. was supported by Instituto de Salud Carlos III (Grant CES10/021-I3SNS). C.D. and H.d.P. are affiliates and members of the European Union Seventh Framework Programme Network of Excellence EviMalaR.