Journal article

Dual-Axis Hormonal Covariation in Adolescence and the Moderating Influence of Prior Trauma and Aversive Maternal Parenting

Julian G Simmons, Michelle L Byrne, Orli S Schwartz, Sarah L Whittle, Lisa Sheeber, Michael Kaess, George J Youssef, Nicholas B Allen



Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes and increase risk for negative health outcomes. The interplay between these axes and the environment is complex, and understanding needs to be advanced by the investigation of the multiple hormonal relationships underlying these processes. The current study examined basal hormonal associations between morning levels of cortisol, testosterone, and dehydroepiandrosterone in a cohort of adolescents (mean age 15.56 years). The moderating influence of childhood adversity was also examined, as indexed by self-reported trauma (at mean age 14.91), and observed maternal ag..

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Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council (ARC; Discovery)

Funding Acknowledgements

Contract grant sponsor: Colonial Foundation TrustContract grant sponsor: National Health and Medical Research Council (NHMRC; Australia)Contract grant number: 350241Contract grant sponsor: Australian Research Council (ARC; Discovery)Contract grant number: DP0878136Contract grant sponsor: University of Melbourne