Journal article

Interfacing Materials Science and Biology for Drug Carrier Design

Georgina K Such, Yan Yan, Angus PR Johnston, Sylvia T Gunawan, Frank Caruso

ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2015

Abstract

Over the last ten years, there has been considerable research interest in the development of polymeric carriers for biomedicine. Such delivery systems have the potential to significantly reduce side effects and increase the bioavailability of poorly soluble therapeutics. The design of carriers has relied on harnessing specific variations in biological conditions, such as pH or redox potential, and more recently, by incorporating specific peptide cleavage sites for enzymatic hydrolysis. Although much progress has been made in this field, the specificity of polymeric carriers is still limited when compared with their biological counterparts. To synthesize the next generation of carriers, it is..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian Research Council under the Australian Laureate Fellowship


Awarded by Australian Future Fellowship


Awarded by Discovery Early Career Researcher Award


Funding Acknowledgements

This work was supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project number CE140100036) and by the Australian Research Council under the Australian Laureate Fellowship FL120100030 (F.C.), Australian Future Fellowship FT120100564 (G.K.S.) and FT110100265 (A.P.R.J.), and Discovery Early Career Researcher Award DE130100488 (Y.Y.) schemes.