Journal article

Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics

Luca Cocchi, Martin V Sale, Anton Lord, Andrew Zalesky, Michael Breakspear, Jason B Mattingley

Journal of Neurophysiology | AMER PHYSIOLOGICAL SOC | Published : 2015

Abstract

Normal brain function depends on a dynamic balance between local specialization and large-scale integration. It remains unclear, however, how local changes in functionally specialized areas can influence integrated activity across larger brain networks. By combining transcranial magnetic stimulation with resting-state functional magnetic resonance imaging, we tested for changes in large-scale integration following the application of excitatory or inhibitory stimulation on the human motor cortex. After local inhibitory stimulation, regions encompassing the sensorimotor module concurrently increased their internal integration and decreased their communication with other modules of the brain. T..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council (ARC) Australian Laureate Fellowship


Awarded by ARC Science of Learning Research Centre


Awarded by ARC Centre of Excellence for Integrative Brain Function (ARC Centre Grant)


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This study was supported by a grant from the National and International Research Alliance Program (NIRAP), Queensland State Government, Australia. J. B. Mattingley was supported by an Australian Research Council (ARC) Australian Laureate Fellowship (FL110100103), the ARC Science of Learning Research Centre (SR120300015), and the ARC Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007). M. V. Sale and A. Zalesky were supported by the Australian National Health and Medical Research Council (APP1028210 to M. V. Sale and APP1047648 to A. Zalesky).