Survival into adulthood of patients with atrial isomerism undergoing cardiac surgery

J Bhaskar; JC Galati; P Brooks; G Oppido; IE Konstantinov; CP Brizard; Y D'Udekem

Journal article

Survival into adulthood of patients with atrial isomerism undergoing cardiac surgery

J Bhaskar, JC Galati, P Brooks, G Oppido, IE Konstantinov, CP Brizard, Y D'Udekem

Journal of Thoracic and Cardiovascular Surgery | Published : 2015

DOI: 10.1016/j.jtcvs.2015.01.038

Abstract

Objectives To identify determinants of adverse outcomes in patients with atrial isomerism. Methods Determinants of survival were analyzed for the group as a whole as well as separately for left and right atrial isomerism. Results There were 78 cases with right and 104 with left atrial isomerism. Nineteen patients were not offered surgery; 49 (47%) of those with left atrial isomerism and 60 (77%) with right atrial isomerism were directed to single ventricle palliation. A total of 67 patients died. Survival to 25 years was 62% (95% confidence interval [CI], 53%-69%). Independent predictors of mortality were obstructed total anomalous pulmonary venous drainage (P <.001; hazard ratio [HR], 5.2; ..

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University of Melbourne Researchers

Christian Brizard Author

Igor Konstantinov Author

Yves D'Udekem D'Acoz Author

Grants

Awarded by The National Heart Foundation of Australia Research Program

Funding Acknowledgements

Y.d'U. is a career development fellow of The National Heart Foundation of Australia Research Program (CR 10M 5339) and Australia National Health and Medical Research Council clinician practitioner fellow (1082186). The Victoria government Operational Infrastructure Support Program supported this research project. C.P.B. reports consulting fees from Admedus. All other authors have nothing to disclose with regard to commercial support.