Journal article

Probabilistic MRI Tractography of the Optic Radiation Using Constrained Spherical Deconvolution: A Feasibility Study

Jeremy C Lim, Pramit M Phal, Patricia M Desmond, Andrew D Nichols, Chris Kokkinos, Helen V Danesh-Meyer, Andrew H Kaye, Bradford A Moffat

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

BACKGROUND AND PURPOSE: Imaging the optic radiation (OR) is of considerable interest in studying diseases affecting the visual pathway and for pre-surgical planning of temporal lobe resections. The purpose of this study was to investigate the clinical feasibility of using probabilistic diffusion tractography based on constrained spherical deconvolution (CSD) to image the optic radiation. It was hypothesized that CSD would provide improved tracking of the OR compared with the widely used ball-and-stick model. METHODS: Diffusion weighted MRI (30 directions) was performed on twenty patients with no known visual deficits. Tractography was performed using probabilistic algorithms based on fiber o..

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Grants

Awarded by Australian NHMRC


Awarded by Cancer Australia


Funding Acknowledgements

This work was supported by the Australian NHMRC (566992, 454790), The Royal Melbourne Hospital Neuroscience foundation, The Melbourne Brain Centre, a Melville-Hughes (University of Melbourne) scholarship (ADN), the Royal Australian College of Surgery (ADN) and Cancer Australia (509322). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.