Journal article

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant Staphylococcus aureus

Sarah L Baines, Kathryn E Holt, Mark B Schultz, Torsten Seemann, Brian O Howden, Slade O Jensen, Sebastiaan J van Hal, Geoffrey W Coombs, Neville Firth, David R Powell, Timothy P Stinear, Benjamin P Howden



UNLABELLED: Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persisted in the health care setting for decades, but the basis of its success has not been identified. Taking a collection of 123 ST239 isolates spanning 32 years, we have used population-based functional genomics to investigate the evolution of this highly persistent and successful clone. Phylogenetic reconstruction and population modeling uncovered a previously unrecognized distinct clade of ST239 that was introduced into Australia from Asia and has perpetua..

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