Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant Staphylococcus aureus
Sarah L Baines, Kathryn E Holt, Mark B Schultz, Torsten Seemann, Brian O Howden, Slade O Jensen, Sebastiaan J van Hal, Geoffrey W Coombs, Neville Firth, David R Powell, Timothy P Stinear, Benjamin P Howden
MBIO | AMER SOC MICROBIOLOGY | Published : 2015
UNLABELLED: Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persisted in the health care setting for decades, but the basis of its success has not been identified. Taking a collection of 123 ST239 isolates spanning 32 years, we have used population-based functional genomics to investigate the evolution of this highly persistent and successful clone. Phylogenetic reconstruction and population modeling uncovered a previously unrecognized distinct clade of ST239 that was introduced into Australia from Asia and has perpetua..View full abstract
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Awarded by National Health and Medical Research Council, Australia
This work was funded by the National Health and Medical Research Council, Australia (fellowships APP1023526 to B.P.H., APP1008549 to T.P.S., and APP1061409 to K.E.H.).