Journal article
Beta-amyloid imaging with florbetaben
O Sabri, J Seibyl, C Rowe, H Barthel
Clinical and Translational Imaging | Published : 2015
Abstract
Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative that was developed as a positron emission tomography (PET) tracer for routine clinical application to visualize β-amyloid plaques in the Alzheimer’s disease (AD) brain. The tracer successfully completed a global multicenter phase 0–III development program and was, as a consequence, recently approved by the US Food and Drug Administration and the European Medicines Agency. This review provides an overview on the florbetaben tracer characteristics and preclinical data leading to its human testing. Further, the favorable results of human pharmacokinetics, safety, and dosimetry evaluation of florbetaben are presented. Next, the resul..
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Funding Acknowledgements
Medical writing assistance was provided by Daniel Booth (Bioscript Medical Limited), funded by Piramal Imaging (Berlin, Germany). The support by Norman Koglin (Piramal Imaging) in the preparation of this manuscript is also greatly acknowledged. We further thank all researchers involved in the global florbetaben development program for their tremendous support in bringing this tracer to clinical routine. Last but not least, we wish to acknowledge the remarkable contributions by the research participants and their families. They pass a precious gift on to the next generation of patients with dementia disorders.