Journal article

Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration

Robyn Guymer, Tania Cipriani, Kay D Rittenhouse, Lyndell Lim, Liubov D Robman, Wenlin Li, Wenlian Wang, Shibing Deng, Poulabi Banerjee

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | SPRINGER | Published : 2015

Abstract

PURPOSE: To investigate the plasma levels of amyloid beta (Aβ) and select inflammatory mediators in patients with various stages of AMD compared to that of age-matched controls, and discern a relationship to disease severity. METHODS: Plasma samples were obtained from AMD subjects at various stages of disease-early (drusen only), geographic atrophy (GA), neovascular AMD (CNV)-and from controls of similar age without AMD. Samples were analyzed using a commercially available ELISA kit (sixteen cytokines) or LC/MS/MS (Aβ isotypes). Descriptive statistics were compiled on all analytes. Analysis of covariance (ANCOVA) was conducted to compare each analyte across AMD groups while adjusting for sex..

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