Moderate and late preterm infants exhibit widespread brain white matter microstructure alterations at term-equivalent age relative to term-born controls
Claire E Kelly, Jeanie LY Cheong, Lillian Gabra Fam, Alexander Leemans, Marc L Seal, Lex W Doyle, Peter J Anderson, Alicia J Spittle, Deanne K Thompson
BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2016
Despite the many studies documenting cerebral white matter microstructural alterations associated with very preterm birth (<32 weeks' gestation), there is a dearth of similar research in moderate and late preterm infants (born 32-36 weeks' gestation), who experience higher rates of neurodevelopmental delays than infants born at term (≥ 37 weeks' gestation). We therefore aimed to determine whether whole brain white matter microstructure differs between moderate and late preterm infants and term-born controls at term-equivalent age, as well as to identify potential perinatal risk factors for white matter microstructural alterations in moderate and late preterm infants. Whole brain white matter..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Australian National Health and Medical Research Council (Centre of Clinical Research Excellence)
Awarded by VIDI from Netherlands Organisation for Scientific Research (NWO)
This study was supported by the Australian National Health and Medical Research Council (Project Grant ID 1028822; Centre of Clinical Research Excellence Grant ID 546519; Centre of Research Excellence Grant ID 1060733; Senior Research Fellowship ID 1081288 to P.J.A.; Early Career Fellowship ID 1053787 to J.L.Y.C., ID 1053767 to A.J.S., ID 1012236 to D.K.T.), Murdoch Childrens Research Institute, Clinical Sciences Theme Grant, the Victorian Government Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation. The research of A.L. is supported by VIDI Grant 639.072.411 from The Netherlands Organisation for Scientific Research (NWO).