Validation of a protocol for manual segmentation of the thalamus on magnetic resonance imaging scans
Brian D Power, Fiona A Wilkes, Mitchell Hunter-Dickson, Danielle van Westen, Alexander F Santillo, Mark Walterfang, Christer Nilsson, Dennis Velakoulis, Jeffrey CL Looi
PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2015
We present a validated protocol for manual segmentation of the thalamus on T1-weighted magnetic resonance imaging (MRI) scans using brain image analysis software. The MRI scans of five normal control subjects were randomly selected from a larger cohort recruited from Lund University Hospital and Landskrona Hospital, Sweden. MRIs were performed using a 3.0T Philips MR scanner, with an eight-channel head coil, and high resolution images were acquired using a T1-weighted turbo field echo (T1 TFE) pulse sequence, with resulting voxel size 1×1×1 mm3. Manual segmentation of the left and right thalami and volume measurement was performed on 28-30 contiguous coronal slices, using ANALYZE 11.0 softwa..View full abstract
The study was funded through grants from the Swedish Parkinson Fund and the Swedish Science Council (through the Basal Ganglia Disease Linnaeus Consortium).