Journal article

Validation of a protocol for manual segmentation of the thalamus on magnetic resonance imaging scans

Brian D Power, Fiona A Wilkes, Mitchell Hunter-Dickson, Danielle van Westen, Alexander F Santillo, Mark Walterfang, Christer Nilsson, Dennis Velakoulis, Jeffrey CL Looi

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2015

Abstract

We present a validated protocol for manual segmentation of the thalamus on T1-weighted magnetic resonance imaging (MRI) scans using brain image analysis software. The MRI scans of five normal control subjects were randomly selected from a larger cohort recruited from Lund University Hospital and Landskrona Hospital, Sweden. MRIs were performed using a 3.0T Philips MR scanner, with an eight-channel head coil, and high resolution images were acquired using a T1-weighted turbo field echo (T1 TFE) pulse sequence, with resulting voxel size 1×1×1 mm3. Manual segmentation of the left and right thalami and volume measurement was performed on 28-30 contiguous coronal slices, using ANALYZE 11.0 softwa..

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