Journal article

Expression of insect alpha 6-like nicotinic acetylcholine receptors in Drosophila melanogaster highlights a high level of conservation of the receptor:spinosyn interaction

Trent Perry, Jason Somers, Ying Ting Yang, Philip Batterham



Insecticide research has often relied on model species for elucidating the resistance mechanisms present in the targeted pests. The accuracy and applicability of extrapolations of these laboratory findings to field conditions varies but, for target site resistance, conserved mechanisms are generally the rule rather than the exception (Perry et al., 2011). The spinosyn class of insecticides appear to fit this paradigm and are a pest control option with many uses in both crop and animal protection. Resistance to spinosyns has been identified in both laboratory-selected and field-collected pest insects. Studies using the model insect, Drosophila melanogaster, have identified the nicotinic acety..

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Awarded by Australian Research Council Discovery Grant

Funding Acknowledgements

The authors would like to thank the providers of materials that were used in this study; J. Bishof and K. Basler for providing their pUASattB vector, Bloomington Stock centre for fly lines, the Australian Drosophila Biomedical Research Support Facility for handling quarantine and importing flies, Novartis Animal Health for M. domestica WHO/I sample, Queensland Department of Primary Industries for B.ovis samples and S.W. Baxter for the P. xylostella clone. They would also like to acknowledge sources of funding for the project, Australian Research Council Discovery Grant (DP120100788 - PB) and an Australian Wool Innovation Research Fellowship (TP) and J.N. Peters Bequest Fellowship (TP).